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张部昌(监事长)
发布日期:2016/10/22 23:16:12


张部昌

:     教授

:     副院长 课题组长(PI

E-Mail:    zhbc@ahu.edu.cn

学科类别:       微生物学,生物化学与分子生物学,微生物分子生态学

学习经历

    1987.6              安徽师范大学        学士

    1990.6              安徽大学              硕士

    2002.6              军事医学科学院     博士

主要工作经历:

    1990.7-1993.12       安徽大学         助教

    1994.1-1999.11       安徽大学         讲师

    1999.12-2003.8       安徽大学         副教授

    2003.9-                  安徽大学         教授

    2003                      安徽省高校优秀中青年骨干教师

    2005                      安徽省高校学科拔尖人才

    2009                      安徽省学术与技术带头人后备人选

主要社会兼职:

    中国微生物学会                                                        理事

    中国遗传学会                                                           理事

    中国生物工程学会医药生物技术专业委员会                  副秘书长

    徽省微生物学会                                                     副理事长

    安徽省遗传学会                                                        副理事长

    安徽省生物工程学会                                                 副理事长

    安徽省医药生物技术协会                                           副理事长

    安徽省农产品加工技术协会                                        副理事长

    安徽省食用菌技术协会                                              常务理事   专家组副组长

    中国科学院离子束生物工程重点实验室                        学术委员会委员

    教育部农产品生物化工工程技术研究中心                     技术委员会委员

 合肥市科普工作者协会                                              副会长

主要研究领域: 

    1、微生物分子生物学

    2、人源化抗体药物

    3、食品生物技术

承担科研项目情况: 

    1 张部昌主持  国家自然科学基金  糖多孢红霉菌TetR家族中与红霉素合成相关转录因子的调控网络构建(31570074)(81万,2016-2019);

    2、张部昌主持  973”项目“合成微生物体系的适配性研究”(2013CB734000)子课题(107万,2013-2017);

    3 张部昌与DAVID WEAVER教授联合主持  人源化抗体研究  横向课题(250万,2012-2017);

    4、张部昌主持  安徽省教育厅自然科学基金重点项目(4万,2012-2014);

    5、金种子人工窖泥快速培养工艺技术研究(金种子集团,150万,2015);

    6、张部昌主持  蛋白表达、纯化技术的研究和应用(通用生物系统(安徽)有限公司,14,2016)。 

代表论著: 

    一、科技成果奖

      1、刘增武,张部昌,许德宏,方玉明,孙钧.甘三酯分子重构塑性脂肪新工艺技术研究与应用.安徽省科技三等奖(证书编号2013-3-R2)

      2、陈彦,开桂青,李绍飞,蒋国梁,张部昌,沈业寿.牡丹皮活性物质的综合制备工艺及产业化.安徽省科技三等奖(证书编号2011-3-R5)

      3、张部昌,余嗣明,李平生,黄训端.生物化学教学改革与本科生素质培养.安徽省教学成果三等奖(证书编号2008203-1

      4、鲁中祝,朱国萍,王钰,张部昌,张宏胜,陈开喜,贺文畅,蒋山.茅仙香菇1.淮南市科技二等奖(证书编号2011-2-R4)

  二、 授权发明专利

   1、张部昌,马清钧,赵志虎. 3-去氧-3-羰基-红霉内酯B,它的工程菌株及应用(ZL01123629.9

   2、任志林,张部昌,许德宏,刘增武,孙钧,张贤兵,范伟,江明星,邵洁. 一种涂抹性奶油的生产方法(ZL 2012 1 0030560.2

   3、张部昌,范伟,黄训端,罗银倩,许德宏,广业贵,刘增武,孙钧,方玉明,江明星,鲁中宝,周三长,程兴. 一种月饼专用油脂及其制备方法(ZL 2013 1 0461072.1

   4、张部昌,刘敬涛,吴杭,袁莉. 通过糖多孢红霉菌SACE_7301基因途径提高红霉素产量(ZL 2013 1 0082765.X

   5、戴维·威孚, 曹诚, 靳彦文, 米歇尔·瑞奇韦兹, 张部昌, 朱林, 贾茹, 姚溢, 温重政. CD20抗原的抗体L1H1及其应用. (ZL 2014 1 0121092.9)

   6、戴维·威孚, 王相芳, 曹诚, 靳彦文, 米歇尔·瑞奇韦兹, 张部昌, 朱林, 贾茹, 姚溢. CD20抗原的抗体L4H6及其应用(ZL 2014 1 0122716.9)

   7、戴维·威孚, 杨凌, 曹诚, 靳彦文, 米歇尔·瑞奇韦兹, 张部昌, 朱林, 贾茹, 姚溢. CD20抗原的抗体L5H6及其应用(ZL 2014 1 0120367.7

   8、戴维·威孚, 曹诚, 靳彦文, 米歇尔·瑞奇韦兹, 张部昌, 朱林, 贾茹. CD20抗原的抗体L4H5及其应用(ZL 2014 1 0119482.2

  三、 代表性论文

        1. Li C, Wang Y, Xie G, Peng B, Zhang B, Chen W, Huang X, Wu H, Zhang B. Complete genome sequence of Clostridium butyricum JKY6D1 isolated from the pit mud of a Chinese flavor liquor-making factory. J Biotechnol. 2016,220:23-4

        2. Wu H, Li W, Xin C, Zhang C, Wang Y, Ren S, Ren M, Zhao W, Yuan L, Xu Z, Yuan H, Geng M, Zhang L, Weaver DT, Zhang B. In vivo investigation to the macrolide-glycosylating enzyme pair DesVII/DesVIII in Saccharopolyspora erythraea. Appl Microbiol Biotechnol. 2016,100(5):2257-66.

        3. Xu C, Yang L, Yuan Y, Du F, Wang S, Wang X, Zhu L, Zhang B, Weaver D. Up-regulation of CYLD enhances Listeria monocytogenes induced apoptosis in THP-1 cells. Microb Pathog. 2016,90:50-4.

        4. Ning P, Jiang J, Li L, Wang S  , Yu H, Feng Y, Zhu M, Zhang B, Yin H, Guo Q, Meng X. A mitochondria-targeted ratiometric two-photon fluorescent probe for biological zinc ions detection. Biosens Bioelectron. 2016 Mar 15;77:921-7.

        5. Li Y, Wan Y, Liu P, Zhao J, Lu G, Qi J, Wang Q, Lu X, Wu Y, Liu W, Zhang B, Yuen KY, Perlman S, Gao GF, Yan J. A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein. Cell Res. 2015,25(11):1237-49

        6. Yang X, Wang C, Xu C, Yan Z, Wei C, Guan K, Ma S, Cao Y, Liu L, Zou D, He X, Zhang B, Ma Q, Zheng Z. miR-526aregulates apoptotic cell growth in human carcinoma cells. Mol Cell Biochem. 2015,407(1-2):69-76.

        7. Yin H, Zhang B, Yu H, Zhu L, Feng Y, Zhu M, Guo Q, Meng X. Two-photon fluorescent probes for biological Mg(2+) detection based on 7-substituted coumarin. J Org Chem. 2015,80(9):4306-12.

        8. Xie F, Dai S, Shen J, Ren B, Huang P, Wang Q, Liu X, Zhang B, Dai H, Zhang L. A new salicylate synthase AmS is identified for siderophores biosynthesis in Amycolatopsis methanolica 239(T). Appl Microbiol Biotechnol. 2015 Jul;99(14):5895-905.

        9. Hang Wu, Yongrong Mao, Meng Chen, Hui Pan, Xunduan Huang , Min Ren, Hao Wu, Jiali Li, Zhongdong Xu, Hualing Yuan, Ming Geng, David T. Weaver*, Lixin Zhang*, Buchang Zhang *. Capturing the target genes of  BldD in Saccharopolyspora erythraea using  improved genomic SELEX method. Applied Microbiology and Biotechnology2015,99(6):2683-2692

      10. Hang Wu, Meng Chen, Yongrong Mao, Weiwei Li, Jingtao Liu, Xunduan Huang , Ying Zhou, Bang-ce Ye, Lixin Zhang, David T Weaver, Buchang Zhang*. Dissecting and engineering of the TetR family regulator SACE_7301 for enhanced erythromycin production in Saccharopolyspora erythraea. Microbial Cell Factories 2014, 13:158.

      11.  Zhuo Y, Zhang T, Wang Q, Cruz-Morales P, Zhang B, Liu M, Barona-Gómez F, Zhang L. Synthetic biology of avermectin for production improvement and structure diversification. Biotechnol J. 2014,9(3):316-25.

      12.  Zhang HM, Dai H, Hanson PJ, Li H, Guo H, Ye X, Hemida MG, Wang L, Tong Y, Qiu Y, Liu S, Wang F, Song F, Zhang B, Wang JG, Zhang LX, Yang D. Antiviral activity of an isatin derivative via induction of PERK-Nrf2-mediated suppression of cap-independent translation. ACS Chem Biol. 2014,9(4):1015-24.

      13.  Yao LL, Liao CH, Huang G, Zhou Y, Rigali S, Zhang B, Ye BC. GlnR-mediated regulation of nitrogen metabolism in the actinomycete Saccharopolyspora erythraea. Appl Microbiol Biotechnol. 2014,98(18):7935-48.

      14.  Xu C, He X, Zheng Z, Zhang Z, Wei C, Guan K, Hou L, Zhang B, Zhu L, Cao  Y, Zhang Y, Cao Y, Ma S, Wang P, Zhang P, Xu Q, Ling Y, Yang X, Zhong H. Downregulation of MicroRNA miR-526a by Enterovirus Inhibits RIG-I-Dependent Innate Immune Response. J Virol. 2014,88(19):11356-68.

      15.  Ling Y, Zhang X, Bai Y, Li P, Wei C, Song T, Zheng Z, Guan K, Zhang Y, Zhang B, Liu X, Ma RZ, Cao C, Zhong H, Xu Q. Overexpression of Mps1 in colon cancer cells attenuates the spindle assembly checkpoint and increases aneuploidy. Biochem Biophys Res Commun. 2014,450(4):1690-5.

      16.  Wang Y, Zhang B, Zhu L, Li Y, Huang F, Li S, Shen Y, Xie A. Preparation and Multiple Antitumor Properties of AuNRs/Spinach Extract/PEGDA Composite Hydrogel. ACS Appl Mater Interfaces. 2014,6(17):15000-6.

      17.  Panpan Wu, Hui Pan, Congming Zhang, Hang Wu, Li Yuan, Xunduan Huang, Ying Zhou, Bang-ce Ye, David T. Weaver , Lixin Zhang, Buchang Zhang*. SACE_3986, a TetR family 1 transcriptional regulator, negatively controls  erythromycin biosynthesis in Saccharopolyspora erythraea. J Ind Microbiol Biotechnol. 2014,41(7):1159-67.

     18. Wei C, Cao Y, Yang X, Zheng Z, Guan K, Wang Q, Tai Y, Zhang Y, Ma S, Cao Y, Ge X, Xu C, Li J, Yan H, Ling Y, Song T, Zhu L, Zhang B, Xu Q, Hu C, Bian XW, He X, Zhong H. Elevated expression of TANK-binding kinase 1 enhances tamoxifen resistance in breast cancer. Proc Natl Acad Sci U S A. 2014,111(5):E601-10.

     19.Zhuo Y, Zhang T, Wang Q, Cruz-Morales P, Zhang B, Liu M, Barona-Gómez F, Zhang L. Synthetic biology of avermectin for production improvement and structure diversification. Biotechnol J. 2014,9(3):316-25.

     20. Huifang M. Zhang,Huanqin Dai,Paul J. Hanson,Huidong Li,Hui Guo,Xin Ye,Maged G. Hemida,Luoqiang Wang,YaojunTong,Ye Qiu,Selina Liu,Fengping Wang,Fuhang Song,Buchang Zhang,Jian-Guo Wang*,Li-Xin Zhang*, and Decheng Yang*. Antiviral Activity of an Isatin Derivative via Induction of PERK-Nrf2-Mediated Suppression of Cap-Independent Translation. ACS Chem Biol. 2014,9(4):1015-24.

     21. Xiaojuan YinXinqiang XuHang WuLi YuanXunduan Huang, Buchang Zhang*. SACE_0012, a TetR family transcriptional regulator, affects the morphogenesis of Saccharopolyspora erythraea. Curr Microbiol, 2013676):647-651

     22. Zhang S, Lu G, Qi J, Li Y, Zhang Z, Zhang B, Fan Z, Yan J, Gao GF. Competition of Cell Adhesion and Immune Recognition: Insights into the Interaction between CRTAM and Nectin-like 2. Structure. 2013,21(8):1430-9.

     23.Lu G, Hu Y, Wang Q, Qi J, Gao F, Li Y, Zhang Y, Zhang W, Yuan Y, Bao J, Zhang B, Shi Y, Yan J, Gao GF. Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature. 2013,500(7461):227-31.

     24. Cheng Xing, Pu You-guang, Zhu Chen-xi, Ren Zhi-lin, Jiang Ming-xing, Chen Yan and Zhang Bu-chang*. Screening of thermophilic neutral lipase-producing Pseudomonas sp. ZBC1 and improving its enzymatic activity. African Journal of Biotechnology, 2013,12(9): 949-957

     25. Zhigang Qiu, Yunmei Yu, Zhaoli Chen, Min Jin, Dong Yang, Zuguo Zhao, Jingfeng Wang, Zhiqiang Shen, Xinwei Wang, Di Qian, Aihua Huang, Buchang Zhang, Jun-Wen Li. Nanoalumina promotes the horizontal transfer of multiresistance genes mediated by plasmids across genera. PNAS 2012109 13):4944-4949

     26. Shu HanPing SongTing RenXunduan HuangCheng Cao Buchang Zhang*. Identification of SACE_7040, a Member of TetR Family Related to the Morphological Differentiation of Saccharopolyspora erythraea.  Curr Microbiol2011 632:121125

     27. Tingting Wang, Liangbao Yang, Buchang Zhang, Jinhuai Liu. Extracellular biosynthesis and transformation of selenium nanoparticles and application in H2O2 biosensor. Colloids and Surfaces B: Biointerfaces2010801):94-102

     28. Chengjun Wang, Jiarui Huang, JinWang, Cuiping Gu, JunhaiWang, Buchang Zhang,  Jinhuai Liu. Fabrication of the nanogapped gold nanoparticles film for direct electrical detection of DNA and EcoRI endonuclease. Colloids and Surfaces B: Biointerfaces. 20096999104

     29.Xinran Liu, Bianhua Liu, Zhenyang Wang, Buchang Zhang, Zhongping Zhang. Oriented Vaterite CaCO3 Tablet-Like Arrays Mineralized at Air/Water Interface through Cooperative Regulation of Polypeptide and Double Hydrophilic Block Copolymer. J. Phys. Chem. C 2008, 112, 96329636

 





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